1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Proton Pump

Proton Pump

Proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on theQ cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. It is an active pump, that generates a protonconcentration gradient across the inner mitochondrial membrane, because there are more protons outside the matrix than inside. The difference in pH and electric charge (ignoring differences inbuffer capacity) creates an electrochemical potential difference that works similar to that of a battery or energy storing unit for the cell. The process could also be seen as analogous to cycling uphill or charging a battery for later use, as it produces potential energy. The proton pump does not create energy, but forms a gradient that stores energy for later use.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13662BR
    (R)-Lansoprazole (Standard)
    Inhibitor
    (R)-Lansoprazole (Standard) is the analytical standard of (R)-Lansoprazole. This product is intended for research and analytical applications. (R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    (R)-Lansoprazole (Standard)
  • HY-Z3707
    N3-Methyl pantoprazole
    N3-Methyl pantoprazole is an impurity of Pantoprazole (HY-17507).
    N3-Methyl pantoprazole
  • HY-B0656AS3
    Rabeprazole-13C,d3 sodium
    Inhibitor
    Rabeprazole-13C,d3 (sodium) (LY307640-13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.
    Rabeprazole-<sup>13</sup>C,d<sub>3</sub> sodium
  • HY-129693
    PBI 51
    Activator
    PBI 51 is an (+)-abscisic acid (ABA) antagonist that blocks the induction of napin and oleosin gene expression by ABA. PBI 51 acts as a weak ABA agonist at high concentration.
    PBI 51
  • HY-138187
    4-Hydroxy omeprazole sulfide
    Control
    4-Hydroxy omeprazole sulfide is a metabolite of the proton pump inhibitor Omeprazole (HY-B0113).
    4-Hydroxy omeprazole sulfide
  • HY-17507E
    S-Pantoprazole sodium trihydrate
    Inhibitor
    S-Pantoprazole (sodium trihydrate) is related to Pantoprazole (HY-17507) that plays an important roles in gastric acid secretion disorder-related diseases, or as proton pump inhibitor.
    S-Pantoprazole sodium trihydrate
  • HY-17623R
    Tegoprazan (Standard)
    Inhibitor
    Tegoprazan (Standard) is the analytical standard of Tegoprazan. This product is intended for research and analytical applications. Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro.
    Tegoprazan (Standard)
  • HY-124158
    KR-60436
    Inhibitor
    KR-60436 is a reversible H+/K+-ATPase inhibitor. KR-60436 can potently inhibit the metabolism of CYP1A2 substrates.
    KR-60436
  • HY-17022R
    Esomeprazole magnesium trihydrate (Standard)
    Inhibitor
    Esomeprazole magnesium (trihydrate) (Standard) is the analytical standard of Esomeprazole magnesium (trihydrate). This product is intended for research and analytical applications. Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases.
    Esomeprazole magnesium trihydrate (Standard)
  • HY-15384
    Picoprazole
    Inhibitor
    Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.
    Picoprazole
  • HY-U00042
    SKF96067
    Inhibitor
    SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.
    SKF96067
  • HY-B0656R
    Rabeprazole (Standard)
    Inhibitor
    Rabeprazole (Standard) is the analytical standard of Rabeprazole. This product is intended for research and analytical applications. Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux.
    Rabeprazole (Standard)
  • HY-75424A
    2-(Trifluoromethyl)cinnamic acid
    Inhibitor 99.77%
    2-(Trifluoromethyl)cinnamic acid is a cinnamic acid derivative that inhibits the proton pump (H+/K+-ATPase), thereby reducing gastric acid secretion. 2-(Trifluoromethyl)cinnamic acid also improves delayed gastric emptying and can be used in research on gastric diseases such as acute gastritis and gastric ulcers.
    2-(Trifluoromethyl)cinnamic acid
  • HY-B0113S4
    Omeprazole-d3 sodium
    Inhibitor
    Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    Omeprazole-d<sub>3</sub> sodium
  • HY-N7031R
    (±)?-?Vasicine (Standard)
    Inhibitor
    (±)?-Vasicine (Standard) is the analytical standard of (±)?-Vasicine. This product is intended for research and analytical applications. (±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H+-K+-ATPase activity in vitro with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect.
    (±)?-?Vasicine (Standard)
  • HY-B0656S1
    Rabeprazole-13C,d3
    Inhibitor
    Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole. Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux.
    Rabeprazole-<sup>13</sup>C,d<sub>3</sub>
  • HY-B0572R
    Zinc Pyrithione (Standard)
    Inhibitor
    Zinc Pyrithione (Standard) is the analytical standard of Zinc Pyrithione. This product is intended for research and analytical applications. Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis.
    Zinc Pyrithione (Standard)
  • HY-N14425
    Concanamycin E
    Inhibitor
    Concanamycin E is a lysosomal acidification inhibitor with an IC50 value of 0.038 nM.
    Concanamycin E
  • HY-117225
    Pantoprazole sulfone
    Control
    Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor Pantoprazole (HY-17507).
    Pantoprazole sulfone
  • HY-19153
    Nepaprazole
    Inhibitor
    Nepaprazole (rel-TY-11345 free base) is a proton pump inhibitor. Nepaprazole inhibits H+/K+-ATPase activity in isolated rabbit gastric mucosal microsomes with the IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively. Nepaprazole can be used for study of peptic ulcer diseases.
    Nepaprazole
Cat. No. Product Name / Synonyms Application Reactivity