1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Proton Pump

Proton Pump

Proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on theQ cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. It is an active pump, that generates a protonconcentration gradient across the inner mitochondrial membrane, because there are more protons outside the matrix than inside. The difference in pH and electric charge (ignoring differences inbuffer capacity) creates an electrochemical potential difference that works similar to that of a battery or energy storing unit for the cell. The process could also be seen as analogous to cycling uphill or charging a battery for later use, as it produces potential energy. The proton pump does not create energy, but forms a gradient that stores energy for later use.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-174258
    ATPase-IN-6
    Inhibitor
    ATPase-IN-6 is a H+/K+- ATPase inhibitor and a prazole derivative. ATPase-IN-6 has significant antiviral activity against multiple viruses, such as HIV-1 and SARS-COV2. ATPase-IN-6 can be used for antiviral infections research.
    ATPase-IN-6
  • HY-N12413
    Apicularen B
    Inhibitor
    Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis.
    Apicularen B
  • HY-100007R
    Vonoprazan (Standard)
    Inhibitor
    Vonoprazan (Standard) is the analytical standard of Vonoprazan. This product is intended for research and analytical applications. Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori.
    Vonoprazan (Standard)
  • HY-101664R
    Ilaprazole (Standard)
    Inhibitor
    Ilaprazole (Standard) is the analytical standard of Ilaprazole. This product is intended for research and analytical applications. Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor.
    Ilaprazole (Standard)
  • HY-123754
    AGN-201904
    Inhibitor
    AGN-201904 is a proton pump inhibitor. AGN-201904 is an omeprazole prodrug that can delay aging and can be used to prevent and treat peptic ulcers.
    AGN-201904
  • HY-17507R
    Pantoprazole (Standard)
    Inhibitor
    Pantoprazole (Standard) is the analytical standard of Pantoprazole. This product is intended for research and analytical applications. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142).
    Pantoprazole (Standard)
  • HY-100412R
    Linaprazan (Standard)
    Inhibitor
    Linaprazan (Standard) is the analytical standard of Linaprazan. This product is intended for research and analytical applications. Linaprazan (AZD0865) can inhibit H+,K+ -ATPase in the stomach through K+ competitive binding, (IC50: 1.0 ± 0.2 μM), it has a strong inhibitory effect on acid. Linaprazan (AZD0865) can be used for research on reflux esophagitis with oral activity.
    Linaprazan (Standard)
  • HY-169551
    ATPase-IN-5
    Inhibitor
    ATPase-IN-5 (compound 11) is a potent inhibitor of Pma1p-ATPase, with the IC50 of 12.7 μM. ATPase-IN-5 plays an important role in anti-fungal research.
    ATPase-IN-5
  • HY-N2033R
    Chebulinic acid (Standard)
    Inhibitor
    Chebulinic acid (Standard) is the analytical standard of Chebulinic acid. This product is intended for research and analytical applications. Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.
    Chebulinic acid (Standard)
  • HY-13662BR
    (R)-Lansoprazole (Standard)
    Inhibitor
    (R)-Lansoprazole (Standard) is the analytical standard of (R)-Lansoprazole. This product is intended for research and analytical applications. (R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
    (R)-Lansoprazole (Standard)
  • HY-Z3707
    N3-Methyl pantoprazole
    N3-Methyl pantoprazole is an impurity of Pantoprazole (HY-17507).
    N3-Methyl pantoprazole
  • HY-B0656AS3
    Rabeprazole-13C,d3 sodium
    Inhibitor
    Rabeprazole-13C,d3 (sodium) (LY307640-13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.
    Rabeprazole-<sup>13</sup>C,d<sub>3</sub> sodium
  • HY-129693
    PBI 51
    Activator
    PBI 51 is an (+)-abscisic acid (ABA) antagonist that blocks the induction of napin and oleosin gene expression by ABA. PBI 51 acts as a weak ABA agonist at high concentration.
    PBI 51
  • HY-138187
    4-Hydroxy omeprazole sulfide
    Control
    4-Hydroxy omeprazole sulfide is a metabolite of the proton pump inhibitor Omeprazole (HY-B0113).
    4-Hydroxy omeprazole sulfide
  • HY-17507E
    S-Pantoprazole sodium trihydrate
    Inhibitor
    S-Pantoprazole (sodium trihydrate) is related to Pantoprazole (HY-17507) that plays an important roles in gastric acid secretion disorder-related diseases, or as proton pump inhibitor.
    S-Pantoprazole sodium trihydrate
  • HY-15295R
    Vonoprazan Fumarate (Standard)
    Inhibitor
    Vonoprazan (Fumarate) (Standard) is the analytical standard of Vonoprazan (Fumarate). This product is intended for research and analytical applications. Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease.
    Vonoprazan Fumarate (Standard)
  • HY-17623R
    Tegoprazan (Standard)
    Inhibitor
    Tegoprazan (Standard) is the analytical standard of Tegoprazan. This product is intended for research and analytical applications. Tegoprazan (CJ-12420), a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro.
    Tegoprazan (Standard)
  • HY-124158
    KR-60436
    Inhibitor
    KR-60436 is a reversible H+/K+-ATPase inhibitor. KR-60436 can potently inhibit the metabolism of CYP1A2 substrates.
    KR-60436
  • HY-15384
    Picoprazole
    Inhibitor
    Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM.
    Picoprazole
  • HY-U00042
    SKF96067
    Inhibitor
    SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.
    SKF96067
Cat. No. Product Name / Synonyms Application Reactivity